Pair Name	Phenethyl isothiocyanate, Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Up-regulation	Cleavage	CASP8	hsa841
	Down-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Phosphorylation	EIF2AK3	hsa9451
	Up-regulation	Phosphorylation	EIF2S1	hsa1965
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	PMAIP1	hsa5366
In Vitro Model	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
	SK-MES-1	Lung squamous cell carcinoma	Homo sapiens (Human)	CVCL_0630
In Vivo Model	NCI‐H1299 cells were subcutaneouslyinjected into the flank of mice.Mice were randomly divided into four groups (four mice pergroup) when the tumor size reached approximately 10 mm3.
Result	We explored the prospect of PEITC in improving the efficacy of targeted drug therapy and demonstrated the synergistic effects and underlined mechanisms of PEITC combined with Gefitinib in NSCLC cells treatment. This study provided useful information for developing novel therapy strategies by combination treatment of PEITC with targeted drugs.